Mass photometry enables label-free tracking and mass measurement of celibe proteins on lipid bilayers

As such, mass photometry could be ideally suited puro address the shortcomings of existing fluorescence-based techniques for in vitro applications sicuro studying IMPs and MAPs

State-of-the-art solo-molecule approaches rely largely on the additif of fluorescent labels, which complicates the quantification of the involved stoichiometries and dynamics because of low temporal resolution and the inherent limitations associated with labeling efficiency, photoblinking and photobleaching. Here, we demonstrate dynamic mass photometry, a method for label-free imaging, tracking and mass measurement of individual membrane-associated proteins diffusing on supported lipid bilayers.

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